Using the genetic characteristics of Neisseria gonorrhoeae strains with decreased susceptibility to cefixime to develop a molecular assay to predict cefixime susceptibility
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چکیده
منابع مشابه
Decreased susceptibility of Neisseria gonorrhoeae isolates from Switzerland to cefixime and ceftriaxone: Antimicrobial susceptibility
203 words) Background Neisseria gonorrhoeae can rapidly develop resistance to antimicrobial agents. Over the last years, decreased gonococcal susceptibility to third-generation cephalosporins, especially cefixime, emerged worldwide. Therefore, current international guidelines recommend dual therapy for gonorrhoea with ceftriaxone plus either azithromycin or doxycycline. Gonococcal susceptibilit...
متن کاملMultidrug-resistant Neisseria gonorrhoeae with decreased susceptibility to cefixime-Hawaii, 2001.
We report 4 urogenital Neisseria gonorrhoeae isolates recovered from 3 patients that demonstrated resistance to penicillin, tetracycline, and ciprofloxacin and reduced susceptibility to cefixime. This report of the first 3 patients in the United States identified with this multidrug-resistant strain may portend an emerging problem for clinicians and public health officials.
متن کاملEmergence of a Neisseria gonorrhoeae clone showing decreased susceptibility to cefixime in England and Wales.
OBJECTIVES The third-generation cephalosporins recommended in national guidelines are amongst the last remaining effective agents for treatment of gonorrhoea. This study characterizes gonococcal isolates with decreased cefixime susceptibility from England and Wales. METHODS A total of 96 isolates of Neisseria gonorrhoeae exhibiting cefixime MICs of ≥0.125 mg/L, either collected as part of the...
متن کاملDecreased Susceptibility of Neisseria Gonorrhoeae to Fluoroquinolones
Antibiotic-resistant isolates of Neisseria gonorrhoeae remain an important public health problem. Fluoroquinolones, such as ciprofloxacin, have excellent penetration into the genitourinary tract and have been shown to be highly active against N. gonorrhoeae, including penicillinase-producing strains (PPNG). However, strains with decreased susceptibility to fluoroquinolones have been reported in...
متن کاملNeisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA.
The recent emergence and transmission of Neisseria gonorrhoeae isolates with reduced susceptibility to expanded-spectrum cephalosporins such as cefixime and ceftriaxone have been reported. The aim of this study was to determine the correlation of different polymorphisms in the penA, mtrR, porB1b (penB), and ponA genes of N. gonorrhoeae with reduced susceptibility to cefixime and ceftriaxone. Ei...
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ژورنال
عنوان ژورنال: Sexual Health
سال: 2019
ISSN: 1448-5028
DOI: 10.1071/sh18227